Change of Fecal Flora and Effectiveness of the Short-term VSL#3 Probiotic Treatment in Patients With Functional Constipation
Journal of Neurogastroenterology and Motility
;
: 111-120, 2015.
Article
in English
| WPRIM
| ID: wpr-14529
ABSTRACT
BACKGROUND/AIMS:
We investigated gut flora characteristics in patients with functional constipation (FC) and influences of short-term treatment with VSL#3 probiotic on flora and symptom improvement.METHODS:
Thirty patients fulfilling Rome III criteria for FC and 30 controls were enrolled. Fecal samples were obtained before and after VSL#3 intake (one sachet twice daily for 2 weeks) and flora were examined by quantitative real-time polymerase chain reaction (qRT-PCR). Symptom changes were also investigated.RESULTS:
The fold differences in Bifidobacterium and Bacteroides species were significantly lower in feces from FC, compared to in controls (P = 0.030 and P = 0.021). After taking VSL#3, the fold differences in Lactobacillus, Bifidobacterium and Bacteroides species increased in controls (P = 0.022, P = 0.018, and P = 0.076), but not in FC. Mean Bristol scores and complete spontaneous bowel movements (CSBMs)/week increased significantly in FC after ingesting VSL#3 (both P < 0.001). Relief of subjective CSBM frequency, stool consistency and abdominal bloating were reported in 70%, 60%, and 47% of patients. After VSL#3 cessation, 44.4% of patients with symptom improvement experienced constipation recurrence mostly within one month.CONCLUSIONS:
Bifidobacterium and Bacteroides species might be quantitatively altered in FC. A short-term VSL#3 treatment can improve clinical symptoms of FC. Further studies are needed to investigate VSL#3's additional effects beyond altering gut flora to allevate constipation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Bacteroides
/
Bifidobacterium
/
Constipation
/
Probiotics
/
Feces
/
Real-Time Polymerase Chain Reaction
/
Microbiota
/
Lactobacillus
Limits:
Humans
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2015
Type:
Article
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