Filtration Effects of Leukocyte Removal Filter for Platelet Concentrates / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 241-245, 1996.
Article
in Korean
| WPRIM
| ID: wpr-145323
ABSTRACT
Some variables can influence the efficiency of leukocyte removal filter for red cell concentrates. We performed this study to evaluate whether the filtration efficiency for platelet concentrates(PCs) can be influenced by bedside filter(PXL8K, Pall Corporation, USA) used, platelet storage time and transient stopping of platelet agitation, and to measure the amount of cytokines released from donor leukocytes in PCs during the storage time. In addition, we examined the effect of leukocyte reduction by filtration before the storage of PCs on the subsequent generation of cytokines. Any of the above mentioned variables did not make significant differences. From day 1 to day 5, there were significant increases in IL-1 beta (<1 vs. 8.6 pg/mL, p<0.05), IL-8 (<10 vs. 455.3 pg/mL, p<0.05) and TNF-alpha (<4 vs. 16.6 pg/mL, p<0.05) in unflltered PCs, whereas no increased revels of cytokines were found in the cases of prestorage filtration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tissue Donors
/
Blood Platelets
/
Cytokines
/
Interleukin-8
/
Tumor Necrosis Factor-alpha
/
Dihydroergotamine
/
Interleukin-1beta
/
Filtration
/
Leukocytes
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
1996
Type:
Article
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