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Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice / 대한배뇨장애요실금학회지
International Neurourology Journal ; : 34-38, 2015.
Article in English | WPRIM | ID: wpr-145430
ABSTRACT

PURPOSE:

It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder.

METHODS:

The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques.

RESULTS:

Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05).

CONCLUSIONS:

The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Arterioles / Venules / Urinary Bladder / Capillaries / Blotting, Western / Fluorescent Antibody Technique / Mice, Knockout / Urothelium / Caveolin 1 / Aquaporin 1 Limits: Animals Language: English Journal: International Neurourology Journal Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Arterioles / Venules / Urinary Bladder / Capillaries / Blotting, Western / Fluorescent Antibody Technique / Mice, Knockout / Urothelium / Caveolin 1 / Aquaporin 1 Limits: Animals Language: English Journal: International Neurourology Journal Year: 2015 Type: Article