Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney / 대한수의학회지
Korean Journal of Veterinary Research
;
: 169-174, 2013.
Article
in English
| WPRIM
| ID: wpr-145460
ABSTRACT
We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and CCl4-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-alpha) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-alpha in the liver. These results indicate that a MAS might have protective effects against ARF and ALF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aspartate Aminotransferases
/
Silicon
/
Blood Urea Nitrogen
/
Mortality
/
Cytokines
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Liver Failure, Acute
/
Creatine
/
Contracts
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Korean Journal of Veterinary Research
Year:
2013
Type:
Article
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