Immunohistochemical localization of galectin-3 in the brain with Theiler's murine encephalomyelitis virus (DA strain) infection / 대한수의학회지
Korean Journal of Veterinary Research
;
: 159-162, 2013.
Article
in English
| WPRIM
| ID: wpr-145462
ABSTRACT
Galectin-3 is a beta-galactoside-binding lectin that plays a role in neuroinflammation through cell migration, proliferation, and apoptosis. In the present study, regulation of galectin-3 was examined in the brain of mice infected with the Daniel strain of Theiler's murine encephalomyelitis virus (TMEV) at days 7 and 81 post-infection by immunohistochemistry. Immunohistochemistry revealed that galectin-3 was mainly localized in ionized calcium-binding adapter 1-positive macrophages/activated microglia, but not in Iba-1-positive ramified microglia. Galectin-3 was also weakly detected in some astrocytes in the same encephalitic lesions, but not in neurons and oligodendrocytes. Collectively, the present findings suggest that galectin-3, mainly produced by activated microglia/macrophages, may be involved in the pathogenesis of virus induced acute inflammation in the early stage as well as the chronic demyelinating lesions in Daniel strain of TMEV induced demyelination model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Viruses
/
Brain
/
Immunohistochemistry
/
Cell Movement
/
Oligodendroglia
/
Astrocytes
/
Demyelinating Diseases
/
Apoptosis
/
Theilovirus
/
Microglia
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Korean Journal of Veterinary Research
Year:
2013
Type:
Article
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