Diagnostic Criteria, Its Sensitivity, and Specificity with the Confocal Scanning Laser Ophthalmoscope TopSSTM

ABSTRACT

This study was conducted to establish glaucomatous diagnostic criteria and to investigate its sensitivity and specificity with the confocal scanning laser ophthalmoscope(TopSSTM) on the basis of the normal values of the optic disc parameters in previous study. Abnormal ratio of optic disc parameters were analysed in 80 primary open angle glaucoma eyes - the subjects were divided into three groups according to visual field defects, each group of mild, moderate, and severe. and then glaucomatous diagnostic critera was established. According to this diagnostic criteria, we calculated its sensitivity and specificity. We established the glaucomatous diagnostic criteria with high sensitive five parameters(1/2 depth area, C/D ratio, neuroretinal rim area(NRRA), volume above, and notching), the established criteria are 1) If NRRA is decreased, one of the four parameters is abnormal. 2) If NRRA is normal, notching and one of the other three parameters are abnormal. Notching was defined as decreased neuroretinal area at either 6 o/c or 12 o/c sector. With this criteria, the sensitivity was 89.7% in mild group and 100% in moderate and severe groups and the specificity was 89.1% in normal groups. This criteria showed high sensitivity and specificity in the diagnosis of glaucoma, so as to be useful in the early detection of glaucomatous spticdisc changes.