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Effects of (−)-Sesamin on Memory Deficits in MPTP-lesioned Mouse Model of Parkinson's Disease
Natural Product Sciences ; : 246-251, 2016.
Article in English | WPRIM | ID: wpr-146021
ABSTRACT
This study investigated the effects of (−)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits including habit learning memory and spatial memory. However, treatment with (−)-sesamin (25 and 50 mg/kg) for 21 days ameliorated memory deficits in MPTP-lesioned mouse model of PD (−)-sesamin at both doses improved decreases in the retention latency time of the passive avoidance test and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid, improved the decreased transfer latency time of the elevated plus-maze test, reduced the increased expression of N-methyl-D-aspartate (NMDA) receptor, and increased the reduced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB). These results suggest that (−)-sesamin has protective effects on both habit learning memory and spatial memory deficits via the dopaminergic neurons and NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mouse model of PD, respectively. Therefore, (−)-sesamin may serve as an adjuvant phytonutrient for memory deficits in PD patients.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Phosphorylation / Phosphotransferases / 3,4-Dihydroxyphenylacetic Acid / Carrier Proteins / Dopamine / Norepinephrine / 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / N-Methylaspartate / Dopaminergic Neurons Limits: Animals / Humans Language: English Journal: Natural Product Sciences Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Phosphorylation / Phosphotransferases / 3,4-Dihydroxyphenylacetic Acid / Carrier Proteins / Dopamine / Norepinephrine / 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / N-Methylaspartate / Dopaminergic Neurons Limits: Animals / Humans Language: English Journal: Natural Product Sciences Year: 2016 Type: Article