Clinicopathlogic and Immunohistochemical Characteristics of Triple Negative Invasive Lobular Carcinoma
Yonsei Medical Journal
;
: 89-97, 2011.
Article
in English
| WPRIM
| ID: wpr-146141
ABSTRACT
PURPOSE:
Our study is performed to find out clinicopathlogic and immunohistochemical (IHC) characteristics of triple negative invasive lobular carcinoma (ILC), as has been demonstrated in their invasive ductal counterparts. MATERIALS ANDMETHODS:
Retrospective analysis of variable clinicopathlogic parameters and IHC stains for androgen receptor, estrogen receptor, progesterone receptor, p53, c-kit, galectin-3, cytokeratin 5 (CK5), CK5/6, vimentin, E-cadherin, epidermal growth factor receptor, and HER2 were performed in 117 cases of ILC.RESULTS:
Eight cases (6.8%) were triple negative carcinoma (TNC), which showed higher incidence of high histologic grade than non-TNC (p = 0.019). Galectin-3 was expressed with higher incidence in tumor cells of TNC (62.5%) than those of non-TNC (7.3%) (p = 0.000). In contrast, galectin-3 was expressed with higher incidence in stromal cells of non-TNC (53.2%) than those of TNC (12.5%) (p = 0.029). CK5 and CK5/6 were not expressed in all ILCs.CONCLUSION:
TNC in ILC showed distinct clinicopathologic and IHC characteristics such as higher histologic grade and increased expression of galectin-3, compared to non-TNC in ILC. TNC in ILC was less frequent and did not show CK5 and CK5/6 expression when compared to TNC in invasive ductal carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vimentin
/
Breast Neoplasms
/
Immunohistochemistry
/
Receptors, Androgen
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Cadherins
/
Carcinoma, Lobular
/
Proto-Oncogene Proteins c-kit
/
Galectin 3
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2011
Type:
Article
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