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The Effect of Lipo-PGE1 on Ischemia-Reperfusion Injury and Endothelin-1 Concentrations After Canine Partial Liver Transplantation / 대한간학회지
The Korean Journal of Hepatology ; : 475-484, 2001.
Article in Korean | WPRIM | ID: wpr-146381
ABSTRACT
BACKGROUND/

AIM:

The lipo-PGE1, known for being more stable during pulmonary circulation and having more targeting effect, has been reported to inhibit ET-1 induced stellate cell contraction. We assessed the effect of lipo-PGE1 on the change of ET-1 concentration and the relationship between ET-1 concentration and the liver damage.

METHODS:

Mongrel dogs weighing about 25 kg were divided into a control (n=6) and a lipo-PGE1 (n=6) group. Partial liver allotransplantation was performed. In the lipo-PGE1 group, lipo-PGE1 was slowly infused through splenic venous cannulation during the donor liver harvesting procedure (50 microgram) and continuously infused (60 microgram/day) for 48 hours after reperfusion. The AST, ALP, LDH and ET-1 concentrations were monitored

RESULTS:

The AST and ALP levels of the lipo-PGE1 group were significantly lower than those of the control group both at 1 hour and 48 hours after reperfusion. The LDH level in the lipo-PGE1 group was lower at 1 hour and 48 hours after reperfusion. But there was no statistical difference between the two groups. The baseline ET-1 concentration of the lipo-PGE1 group was eight times higher than that of the control group. The ET-1 concentration was elevated gradually in the control group. There was no significant difference between the two groups at 48 hours. There was no correlation between ET-1 concentrations and AST, ALP, LDH levels.

CONCLUSION:

This study demonstrated the hepatoprotective effect of the lipo-PGE1 against ischemia-reperfusion injury in canine partial liver allotransplantation. However, the baseline ET-1 level was eight times higher in the lipo-PGE1 group than that of the control group in spite of the hepatoprotective effects of the lipo-PGE1.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Catheterization / Alprostadil / Reperfusion / Reperfusion Injury / Pulmonary Circulation / Liver Transplantation / Endothelin-1 / Liver Limits: Animals / Humans Language: Korean Journal: The Korean Journal of Hepatology Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Catheterization / Alprostadil / Reperfusion / Reperfusion Injury / Pulmonary Circulation / Liver Transplantation / Endothelin-1 / Liver Limits: Animals / Humans Language: Korean Journal: The Korean Journal of Hepatology Year: 2001 Type: Article