Changes of Serum Cytokines After the Long Term Immunotherapy with Japanese Hop Pollen Extracts
Journal of Korean Medical Science
;
: 805-810, 2006.
Article
in English
| WPRIM
| ID: wpr-14645
ABSTRACT
Japanese hop (Hop J) pollen has been considered as one of the major causative pollen allergens in the autumn season. We developed a new Hop J immunotherapy extract in collaboration with Allergopharma (Reinbeck, Germany) and investigated immunologic mechanisms during 3 yr immunotherapy. Twenty patients (13 asthma with rhinitis and 7 hay fever) were enrolled from Ajou University Hospital. Sera were collected before, 1 yr, and 3 yr after the immunotherapy. Changes of serum specific IgE, IgG1 , and IgG4 levels to Hop J pollen extracts and serum IL-10, IL-12, TGF-beta1 and soluble CD23 levels were monitored by ELISA. Skin reactivity and airway hyper-responsiveness to methacholine were improved during the study period. Specific IgG1 increased at 1 yr then decreased again at 3 yr, and specific IgG4 levels increased progressively (p<0.05, respectively), whereas total and specific IgE levels showed variable responses with no statistical significance. IL-10, TGF-beta1 and soluble CD23 level began to decrease during first year and then further decreased during next two years with statistical significances. (p<0.05, respectively). In con-clusion, these findings suggested the favorable effect of long term immunotherapy with Hop J pollen extracts can be explained by lowered IgE affinity and generation of specific IgG4 , which may be mediated by IL-10 and TGF-beta1.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pollen
/
Immunoglobulin E
/
Immunoglobulin G
/
Cytokines
/
Transforming Growth Factor beta
/
Desensitization, Immunologic
/
Interleukin-10
/
Bronchial Hyperreactivity
/
Receptors, IgE
/
Poaceae
Limits:
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2006
Type:
Article
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