Leber's Hereditary Optic Neuropathy with Mitochondrial DNA 11778 Mutation Presenting with Various Types of Seizures
Journal of the Korean Neurological Association
;
: 498-502, 2006.
Article
in Korean
| WPRIM
| ID: wpr-14657
ABSTRACT
Leber's hereditary optic neuropathy (LHON) is a mitochondrial genetic disease characterized by acute or subacute visual loss associated with other neurologic diseases. We report a man with LHON caused by a mitochondrial DNA point mutation at nucleotide position 11778, who presented various types of seizures, and hydrocephalus. EEG showed frequent brief generalized 2.5~3 Hz spike or polyspikes-and-wave activities. Brain MRI and cisternography showed communicating hydrocephalus. LHON plus associated with epilepsy and hydrocephalus in our patient widens the clinical presentation of LHON.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seizures
/
Brain
/
DNA, Mitochondrial
/
Magnetic Resonance Imaging
/
Point Mutation
/
Optic Atrophy, Hereditary, Leber
/
Electroencephalography
/
Epilepsy
/
Hydrocephalus
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2006
Type:
Article
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