Tumor Necrosis Factor-alpha as a Predictor for the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Follow-Up Study
Endocrinology and Metabolism
;
: 41-45, 2013.
Article
in English
| WPRIM
| ID: wpr-146604
ABSTRACT
BACKGROUND:
Tumor necrosis factor (TNF)-alpha is associated with insulin resistance and systemic inflammatory responses. The aim of this study was to investigate the relationship between TNF-alpha and the development of nonalcoholic fatty liver disease (NAFLD) in a longitudinal study.METHODS:
Three hundred and sixty-three apparently healthy subjects (mean age, 40.5+/-6.1 years; male, 57.6%) without NAFLD were enrolled in 2003. Anthropometric and laboratory measurements were performed. The participants were grouped into tertiles according to their serum TNF-alpha levels from samples taken in 2003. At a 4-year follow-up, we compared the odds ratios (ORs) of the development of NAFLD according to the tertiles of TNF-alpha levels measured in 2003.RESULTS:
At the 4-year follow-up, the cumulative incidence of NAFLD was 29.2% (106/363). The group that developed NAFLD had higher levels of TNF-alpha than those in the group without NAFLD (3.65+/-1.79 pg/mL vs. 3.15+/-1.78 pg/mL; P=0.016). When the 2003 serum TNF-alpha levels were categorized into tertiles incidence of NAFLD observed in 2007 was significantly higher with increasing tertiles (22.6%, 35.8%, and 41.5%, respectively; P<0.05). The risk of developing NAFLD was significantly greater in the highest tertile of TNF-alpha than in the lowest tertile after adjusting for age, smoking, and BMI (OR, 2.20; 95% confidence interval, 1.12 to 4.01; P<0.05).CONCLUSION:
Higher serum TNF-alpha levels in subjects without NAFLD were associated with the development of NAFLD. The results of study might suggest a pathologic role of inflammation in NAFLD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Insulin Resistance
/
Smoking
/
Odds Ratio
/
Incidence
/
Follow-Up Studies
/
Tumor Necrosis Factor-alpha
/
Fatty Liver
/
Inflammation
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2013
Type:
Article
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