Your browser doesn't support javascript.
loading
Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism
Endocrinology and Metabolism ; : 3-5, 2013.
Article in English | WPRIM | ID: wpr-146611
ABSTRACT
To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by the central nervous system. In particular, a comprehension of the fine cellular interplay and intracellular mechanisms that enable appropriate hypothalamic and consequent endocrine and behavioral responses to both circulating hormonal and nutrient signals remains elusive. Recent data, including those from our laboratories, raised the notion that reactive oxygen species (ROS) generation is not merely a by-product of substrate oxidation, but it plays a crucial role in modulating cellular responses involved in the regulation of energy metabolism. These review summarizes the published recent data on the effect of ROS levels in the regulation of neuronal function, including that of hypothalamic melanocortin neurons, pro-opiomelanocortin and neuropeptide Y-/agouti related peptide-neurons, in the modulation of food intake.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Neuropeptides / Pro-Opiomelanocortin / Central Nervous System / Reactive Oxygen Species / Peroxisomes / Comprehension / Eating / Energy Metabolism / Hypothalamus / Neurons Language: English Journal: Endocrinology and Metabolism Year: 2013 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Neuropeptides / Pro-Opiomelanocortin / Central Nervous System / Reactive Oxygen Species / Peroxisomes / Comprehension / Eating / Energy Metabolism / Hypothalamus / Neurons Language: English Journal: Endocrinology and Metabolism Year: 2013 Type: Article