Maternal Separation Does Not Produce a Significant Behavioral Change in Mice
Experimental Neurobiology
; : 390-398, 2017.
Article
in En
| WPRIM
| ID: wpr-146663
Responsible library:
WPRO
ABSTRACT
Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification.
Key words
Full text:
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Index:
WPRIM
Main subject:
Anxiety
/
Weaning
/
Cohort Studies
/
Genetic Predisposition to Disease
/
Models, Animal
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Depression
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Animals
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Humans
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Male
Language:
En
Journal:
Experimental Neurobiology
Year:
2017
Type:
Article