Delay in Normalization of Disrupted Sleep-Wake Cycle in Mice as a Bipolar Disorder-Prone Animal Model (Bipolar Disorder-Prone Animal Model) / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 209-214, 2016.
Article
in Korean
| WPRIM
| ID: wpr-146694
ABSTRACT
OBJECTIVES:
This study was designed to test the hypothesis that delayed recovery from disrupted circadian rhythm is associated with both manic and depressive episodes in bipolar disorder.METHODS:
Twenty-two male mice (age of five weeks, weight 28–30 gm) underwent three days of light-dark cycle disruption and 10 days of recovery phase. Sleep and wake state were checked every five minutes during the entire experimental period. After recovery phase, quinpirole (0.5 mg/kg, s.c.) was injected into the mice and open field locomotor activities were checked. Five days after the open field test, immobility time during the last 4 min in 6 min of forced swimming test was measured. Animals which recovered sleep-wake cycle within six days after light-dark cycle disruption were assigned to the early recovery group (n=14), and those that failed to recover in six days were assigned to the delayed recovery group (n=8). The locomotor activities and the immobility times of the two groups were compared by Mann-Whiney U test at two-tailed significance level of 0.05.RESULTS:
The locomotor activities of the delayed recovery group were higher (mean rank=16.19) than those of the early recovery group (mean rank=8.82, U=18.5, p=0.008). The immobility times did not differ by recovery time (U=32.0 p=0.110).CONCLUSION:
The results suggest that delayed recovery from circadian rhythm disruption raises the risk of manic symptoms rather than depressive symptoms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bipolar Disorder
/
Circadian Rhythm
/
Photoperiod
/
Quinpirole
/
Models, Animal
/
Depression
/
Physical Exertion
/
Motor Activity
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2016
Type:
Article
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