Effects of N-acetylcysteine and Methylprednisolone on Lung Injury in a Paraquat-Poisoned Rat Model
Journal of the Korean Society of Emergency Medicine
;
: 214-221, 2001.
Article
in Korean
| WPRIM
| ID: wpr-147057
ABSTRACT
BACKGROUND:
This study evaluated the inhibitory effects of N-acetylcysteine(NAC) and methylprednisolone on lung injury in the paraquat-poisoned rat model.METHODS:
Sixty rats were divided into four groups(n=15 in each group) accordingly to the drug administered group I, only intraperitoneally injected paraquat (20 mg/kg); group II, intraperitoneally injected paraquat and NAC(300 mg/kg); group III, intraperitoneally injected paraquat and methylprednisolone(60 mg/kg); and group IV, intraperitoneally injected paraquat, NAC(300 mg/kg), and methylprednisolone(60 mg/kg). On the 7th day after injection, the survival rate of experimental rats and the positive area of collagen fiber in the injured lung stained by Masson's trichrome were evaluated.RESULTS:
1. There were no differences in the 7-day survival rates for the four groups. 2. The percent of collagen fiber for group II(6.3+/-4.7%) was significantly decreased in comparison with that for group I (14.4+/-9.7%). 3. The percent of collagen fiber for Group III(13.2+/-5.9%) was not significantly different from that for group I(14.4+/-9.7%). 4. The percent of collagen fiber for Group IV(6.9+/-4.6%) was significantly decreased in comparison with that for group I, but was not different from that for group II.CONCLUSION:
These results suggest that NAC protects against pulmonary fibrosis in paraquat-poisoned rats whereas methylprednisolone does not protect against pulmonary fibrosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraquat
/
Acetylcysteine
/
Pulmonary Fibrosis
/
Methylprednisolone
/
Survival Rate
/
Collagen
/
Models, Animal
/
Lung Injury
/
Lung
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Society of Emergency Medicine
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS