MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
Experimental & Molecular Medicine
;
: e156-2015.
Article
in English
| WPRIM
| ID: wpr-147138
ABSTRACT
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6 production by macrophages in response to LPS has remained unclear, however. We now show that LPS induces IL-6 synthesis in mouse peritoneal macrophages via the leukotriene B4 receptor BLT2. Our results suggest that TLR4-MyD88 signaling functions upstream of BLT2 and that the generation of reactive oxygen species (ROS) by NADPH oxidase 1 (Nox1) and consequent activation of the transcription factor nuclear factor (NF)-kappaB function downstream of BLT2 in this response. These results suggest that a TLR4-MyD88-BLT2-Nox1-ROS-NF-kappaB pathway contributes to the synthesis of IL-6 in LPS-stimulated mouse macrophages.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Cell Line
/
Lipopolysaccharides
/
NF-kappa B
/
Interleukin-6
/
Reactive Oxygen Species
/
Receptors, Leukotriene B4
/
Macrophages, Peritoneal
/
Leukotriene B4
/
Myeloid Differentiation Factor 88
Limits:
Animals
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2015
Type:
Article
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