Apolipoprotein E Genotype in Korean Schizophrenic Patients
Journal of Korean Medical Science
;
: 781-783, 2001.
Article
in English
| WPRIM
| ID: wpr-147204
ABSTRACT
The apolipoprotein E (APOE) epsilon4 allele is a known risk factor for the development of Alzheimer's disease, however, an association of the APOE genotype with schizophrenia is controversial. We investigated the association in 60 Korean schizophrenic patients and 60 healthy controls. APOE genotypes were identified by reverse hybridization-based line probe assay. There were significant differences in the distribution of APOE genotypes between schizophrenic patients and controls. APOE epsilon2 and epsilon3 allele frequencies in schizophrenic patients were significantly different from those in controls. Our results suggest that APOE alleles seem to be operative in the pathogenesis of schizophrenic disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins E
/
Schizophrenia
/
Risk Factors
/
Sex Distribution
/
Age Distribution
/
Genetic Predisposition to Disease
/
Gene Frequency
/
Genotype
/
Korea
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2001
Type:
Article
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