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Long-Term Complete Remission in an Acute Myeloid Leukemia Patient with Isolated Central Nervous System Relapse after Allogeneic Hematopoietic Stem Cell Transplantation / 영남의대학술지
Yeungnam University Journal of Medicine ; : 96-101, 2012.
Article in Korean | WPRIM | ID: wpr-147272
ABSTRACT
Allogeneic hematopoietic stem cell transplantation (HSCT) is considered the optimal curative treatment for acute myeloid leukemia (AML), but some patients develop bone marrow relapse due to remnant leukemia, and few patients develop extramedullary relapse without bone marrow relapse. Isolated extramedullary relapse (IMER) is defined as extramedullary relapse without bone marrow relapse. IMER has been reported in various sites, including the skin, soft tissue, and central nervous system(CNS). Isolated CNS relapse is relatively rare and is associated with poor prognosis due to the absence of an optimal treatment for it. Reported herein is a case involving an adult AML woman who suffered from isolated extramedullary relapse in the CNS after allogeneic HSCT. She was treated with intrathecal chemotherapy and whole-brain and spine radiotherapy, followed by systemic chemotherapy. She is currently well, with no evidence of leukemia recurrence for over six years.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Recurrence / Skin / Spine / Bone Marrow / Hematopoietic Stem Cells / Leukemia, Myeloid, Acute / Leukemia / Central Nervous System / Bone Marrow Transplantation Type of study: Prognostic study Limits: Adult / Female / Humans Language: Korean Journal: Yeungnam University Journal of Medicine Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Recurrence / Skin / Spine / Bone Marrow / Hematopoietic Stem Cells / Leukemia, Myeloid, Acute / Leukemia / Central Nervous System / Bone Marrow Transplantation Type of study: Prognostic study Limits: Adult / Female / Humans Language: Korean Journal: Yeungnam University Journal of Medicine Year: 2012 Type: Article