Elevated Serum Levels of IL-21 in Kawasaki Disease
Allergy, Asthma & Immunology Research
;
: 351-356, 2012.
Article
in English
| WPRIM
| ID: wpr-147280
ABSTRACT
PURPOSE:
The serum level of immunoglobulin (Ig)E has been reported to be elevated in patients with Kawasaki disease (KD). We investigated whether interleukin (IL)-21, rather than IL-4, could be related to elevated serum levels of IgE in KD.METHODS:
Sera from 48 patients with KD and 12 controls with high fever were collected to determine the level of IgE using an immunoassay system and the levels of IL-4 and IL-21 were determined using enzyme-linked immunosorbent assay kits.RESULTS:
The median IL-21 level of KD patients was significantly elevated, at 499.5 pg/mL (range <62.5-1,544 pg/mL), whereas that of controls was <62.5 pg/mL (<62.5-825 pg/mL; P<0.001). The median IL-4 level of KD patients was not elevated (4.0 pg/mL; 2.1-7.6 pg/mL). The median level of total IgE in KD patients was 58.0 IU/mL (5-1,109 IU/mL). No statistically significant correlation was found between IL-21 and total IgE levels (Spearman's R=0.2; P=0.19).CONCLUSIONS:
Patients with KD have elevated levels of IL-21 in the serum. IL-21 may play a role in the pathogenesis of KD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin E
/
Immunoglobulins
/
Enzyme-Linked Immunosorbent Assay
/
Immunoassay
/
Interleukins
/
Interleukin-4
/
Fever
/
Mucocutaneous Lymph Node Syndrome
Limits:
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2012
Type:
Article
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