A case of granulomatous lung disease in a patient with Good's syndrome
The Korean Journal of Internal Medicine
;
: 219-222, 2008.
Article
in English
| WPRIM
| ID: wpr-147564
ABSTRACT
Good's syndrome is extremely rare. This adult-onset condition is characterized by a thymoma with immunodeficiency, low B- and T-cell counts, and hypo-gammaglobulinemia. The initial clinical presentation is either a mass-lesion thymoma or a recurrent infection. Patients with Good's syndrome are very susceptible to infections; common respiratory and opportunistic infections can be life-threatening. There are no reports of granulomatous lung disease in patients with Good's syndrome, although it has been observed in patients with common variable immunodeficiency, of which Good's syndrome is a subset. We describe a 53-year-old male thymoma patient who presented with respiratory symptoms caused by granulomatous lung disease and an opportunistic infection. He died of uncontrolled fungal infection despite repeated intravenous immunoglobulin and supportive care. Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with severe recurrent infections, especially opportunistic infections.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thymoma
/
Thymus Neoplasms
/
Granuloma, Respiratory Tract
/
Fatal Outcome
/
Immunologic Deficiency Syndromes
/
Lung Diseases
Limits:
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2008
Type:
Article
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