Autologous stem cell transplantation for diffuse large B-cell lymphoma with residual extranodal involvement
The Korean Journal of Internal Medicine
;
: 182-190, 2008.
Article
in English
| WPRIM
| ID: wpr-147570
ABSTRACT
BACKGROUND/AIMS:
Diffuse large B-cell lymphoma (DLBCL) in Koreans is frequently accompanied by extranodal (EN) disease at the time of autologous stem cell transplantation (ASCT). We sought to determine whether high EN involvement affected survival following ASCT in Koreans.METHODS:
We reviewed 27 patients who had DLBCL with residual disease at ASCT 13 with residual disease at nodal site(s) only and 14 with nodal and EN disease.RESULTS:
Univariate analysis showed that disease status, lactate dehydrogenase (LDH), and performance status at ASCT were predictors of survival following ASCT. The number of EN sites, as categorized by the International Prognostic Index system, had no prognostic significance. When EN involvement at ASCT was classified as negative or positive, the 2-year overall survival for the negative group was 64%, significantly better than the 14% for the positive group (p=0.021), and the event-free survival for the negative group was 62%, significantly better than the 14% for the positive group (p=0.02).CONCLUSIONS:
Patients who had DLBCL with residual EN involvement at ASCT showed worse outcomes following ASCT compared to those without EN disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Survival Rate
/
Retrospective Studies
/
Cohort Studies
/
Lymphoma, Large B-Cell, Diffuse
/
Treatment Outcome
/
Neoplasm, Residual
/
Stem Cell Transplantation
/
Korea
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2008
Type:
Article
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