Investigation of the Bovine Leukemia Virus Proviral DNA in Human Leukemias and Lung cancers in Korea
Journal of Korean Medical Science
;
: 603-606, 2005.
Article
in English
| WPRIM
| ID: wpr-147619
ABSTRACT
The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA, Viral
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Adenocarcinoma
/
Leukemia
/
Leukemia, Myeloid
/
Cell Line
/
Polymerase Chain Reaction
/
Acute Disease
/
Proviruses
/
Leukemia Virus, Bovine
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2005
Type:
Article
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