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Oral Sildenafil in Persistent Pulmonary Hypertension of the Newborn
Journal of the Korean Society of Neonatology ; : 124-129, 2011.
Article in Korean | WPRIM | ID: wpr-147655
ABSTRACT

PURPOSE:

To evaluate the effect of oral sildenafil therapy in neonates with persistent pulmonary hypertension of the newborn (PPHN)

METHODS:

We conducted a retrospective review of 32 neonates > or =35 weeks' gestation and fraction of inspired oxygen (FiO2) 1.0 with PPHN. The first dose (0.5 mg/kg) of oral sildenafil was started and 1 mg/kg was given every 6 hour thereafter. Mean airway pressure (MAP), FiO2, oxygenation index (OI), mean arterial blood pressure (MBP) were documented before and 6, 12, 24, and 48 hours after sildenafil. For adverse effects, gastrointestinal symptoms, brain ultrasound, funduscopy and auditory brainstem response results were evaluated.

RESULTS:

The underlying diseases of PPHN (n=32) were meconium aspiration syndrome (n=9), respiratory distress syndrome (n=8), pneumonia (n=3), and idiopathic (n=12). Thirty-one neonates survived; 3 neonates were transferred for inhaled nitric oxide (iNO) and all of them survived. In 28 infants, FiO2 and OI improved significantly by 6 hours and MAP improved significantly by 48 hours after initiation of sildenafil. There were no clinically significant adverse effects of sildenafil.

CONCLUSION:

Sildenafil may be an effective and safe agent for near-term and term neonates with PPHN, providing significant improvement in oxygenation, and thus may be especially useful in the treatment of PPHN in hospitals without iNO.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxygen / Piperazines / Pneumonia / Purines / Sulfones / Brain / Meconium Aspiration Syndrome / Retrospective Studies / Evoked Potentials, Auditory, Brain Stem / Arterial Pressure Type of study: Observational study Limits: Humans / Infant / Infant, Newborn / Pregnancy Language: Korean Journal: Journal of the Korean Society of Neonatology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxygen / Piperazines / Pneumonia / Purines / Sulfones / Brain / Meconium Aspiration Syndrome / Retrospective Studies / Evoked Potentials, Auditory, Brain Stem / Arterial Pressure Type of study: Observational study Limits: Humans / Infant / Infant, Newborn / Pregnancy Language: Korean Journal: Journal of the Korean Society of Neonatology Year: 2011 Type: Article