Prognostic Significance of Abnormal beta - catenin Expression in Breast Carcinoma
Korean Journal of Pathology
;
: 114-119, 2005.
Article
in English
| WPRIM
| ID: wpr-147993
ABSTRACT
BACKGROUND:
The subcellular localization and activity of beta-catenin are tightly regulated within the cell. The aim of this study was to analyze the aberrant beta-catenin expression in breast carcinomas and to determine its clinical significance.METHODS:
Fifty five cases of breast carcinoma were immunostained with monoclonal antibodies against beta-catenin. Normal expression of -catenin was defined as exclusive membranous staining. Abnormal expression of beta-catenin was reclassified into 3 categories complete or partial loss of membranous staining (LOM) without cytoplasmic staining and nuclear staining, LOM with cytoplasmic staining and without nuclear staining, and LOM with nuclear staining and with/without cytoplasmic staining.RESULTS:
Normal membranous beta-catenin expression was detected in 25 (45.5%) of 55 cases of breast carcinoma. Thirty cases with abnormal -catenin expression comprised 9 cases (16.1%) showing LOM without cytoplasmic and/or nuclear staining, 20 cases (36.4%) showing LOM with cytoplasmic staining and without nuclear staining, and one case (1.8%) showing LOM with nuclear and cytoplasmic staining. Abnormal beta-catenin expression was significantly correlated with lymph node metastasis (p=0.03). LOM with cytoplasmic and/or nuclear expression was significantly correlated with poor disease free survival by univariate (p=0.03) and multivariate analyses (p=0.03). In addition, it was correlated with poor overall survival with a borderline significance (p=0.059).CONCLUSIONS:
This study suggests that the cytoplasmic and/or nuclear expression of beta-catenin can be used as a biologic marker for predicting disease recurrence and poor patients' survival in breast carcinomas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Breast
/
Breast Neoplasms
/
Immunohistochemistry
/
Biomarkers
/
Multivariate Analysis
/
Carcinoma, Ductal, Breast
/
Disease-Free Survival
/
Cytoplasm
/
Beta Catenin
Type of study:
Prognostic study
Language:
English
Journal:
Korean Journal of Pathology
Year:
2005
Type:
Article
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