Expression of p63,bcl-2,bcl-6 and p16 in Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin
Korean Journal of Pathology
;
: 91-98, 2005.
Article
in English
| WPRIM
| ID: wpr-147996
ABSTRACT
BACKGROUND:
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the common malignant neoplasms of the skin. The p63 is a p53 homologue which is considered to be a reliable keratinocyte stem cell marker. Bcl-2 plays a key role in cell longevity by preventing apoptosis, whereas the bcl-6 gene functions as a transcriptional repressor. The p16-CDK4/6 complex arrests the cell cycle at G0 /G1 phase. In the present study, the expression of p63, bcl-2, bcl-6, and p16 in BCC and SCC was evaluated.METHODS:
Forty-seven BCCs and 43 SCCs were selected and microarrayed in paraffin blocks. Immunohistochemical analysis was performed with specific antibodies for bcl-2, bcl-6, p16 and p63.RESULTS:
p63 was found to be expressed in all BCCs and SCCs. Bcl-2 was exclusively expressed in BCCs (100%), but there was negative expression in SCCs, whereas bcl-6 was positively expressed in 18.2% of SCCs, and was negative in BCCs. In SCCs, p16 was expressed at high frequency (47.7%) than in BCCs (14.9%). The expression of p16 was correlated with the histologic grades of SCCs.CONCLUSION:
The different patterns of bcl-2, bcl-6, p63 and p16 protein expression between BCCs and SCCs may represent the different histogenesis and morphologic features of two lesions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
Skin
/
Stem Cells
/
Carcinoma, Basal Cell
/
Carcinoma, Squamous Cell
/
Keratinocytes
/
Cell Cycle
/
Apoptosis
/
Proto-Oncogene Proteins c-bcl-6
/
Longevity
Language:
English
Journal:
Korean Journal of Pathology
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS