Comparison of bare metal stent and paclitaxel-eluting stent using a novel rat aorta stent model
Journal of Veterinary Science
;
: 143-149, 2011.
Article
in English
| WPRIM
| ID: wpr-148001
ABSTRACT
The purpose of our study was to create a novel rat aorta stent implantation model. Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 +/- 20 g). Two and four weeks after stent implantation, the aorta were collected, fixed with 2% glutaraldehyde, and cut into two segments. One segment was used for scanning electron microscopy analysis to evaluate re-endothelialization, and the other segment was used to calculate the neointimal area. At 2 weeks after stenting, the appearance of neointimal hyperplasia was less in the PES group than in the BMS group. At 4 weeks after stenting, no significant difference in neointimal hyperplasia was observed between two groups. On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group. This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta, Thoracic
/
Coronary Artery Disease
/
Microscopy, Electron, Scanning
/
Paclitaxel
/
Rats, Sprague-Dawley
/
Angioplasty
/
Models, Animal
/
Drug-Eluting Stents
/
Neointima
/
Histocytochemistry
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2011
Type:
Article
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