Changes in Thromboelastographic Findings after Bleeding-Induced Hemodilution in Patients Undergoing Radical Hysterectomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 11-17, 2005.
Article
in Korean
| WPRIM
| ID: wpr-148038
ABSTRACT
BACKGROUND:
Recent studies have produced conflicting results on the influence of hemodilution on the coagulation system. Furthermore, only a few clinical studies have been conducted regarding actual blood loss and associated hemodilution. The purpose of this study was to investigate changes in thromboelastograph (TEG) findings after moderate bleeding-induced hemodilution in patients undergoing radical hysterectomy.METHODS:
23 patients scheduled for radical hysterectomy were included. No patient had a preoperative coagulation abnormality or was receiving anticoagulant or antiplatelet medication. TEG findings 15 min after induction of anesthesia and after an estimated blood loss equaling 15% of the estimated blood volume were compared. Only crystalloid solution was administered until the second blood sampling for TEG analysis in order to produce a hemodilution state.RESULTS:
After hemodilution R time, K time and coagulation time (r + k) showed significant reductions, and alpha angle and TEG index showed significant increases (P < 0.01), and increased coagulability. MA increased after hemodilution, but this was not statistically significant. A60 and CL60 also increased, showing decreased fibrinolysis (P < 0.05).CONCLUSIONS:
Moderate bleeding-induced hemodilution increased coagulability according to TEG compared to pre-hemodilution findings. We recommend that the decision to replace coagulation factors and/or platelets should not be based on empirically derived, arbitrary standards.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Volume
/
Blood Coagulation Factors
/
Fibrinolysis
/
Hemodilution
/
Hysterectomy
/
Anesthesia
Type of study:
Diagnostic study
/
Practice guideline
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2005
Type:
Article
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