The Significance of the Lymphatic Micro Vessel Density and Vascular Endothelial Growth Factor- C Expression for Colorectal Cancer
Journal of the Korean Surgical Society
;
: 406-411, 2007.
Article
in Korean
| WPRIM
| ID: wpr-148067
ABSTRACT
PURPOSE:
Studying the prognostic factors of distant metastasis is quite important for predicting these patients' prognosis and also for providing standards for post-operative adjuvant chemotherapy. Microbiological studies currently enable researchers to look for new predictors of distant metastasis in patients with colon cancers. In this study, the VEGF-C expression and stain rate of D2-40 were investigated as prognostic factors.METHODS:
79 Specimens were collected from the patients who underwent colorectal operation and they were pathologicaly diagnosed with cancer at Chung-Ang University hospital from March, 2003 to Sept. 2005. The specimens were immunohistochemically stained to detect the VEGF-c expression and the D2- 40 stain rate.RESULTS:
The VEGF-C expression was related to lymph node metastasis, tumor embolism and the frequency of the T- stage, but it was not related to progression of cancer. The D2-40 stained lymphatic density was significantly increased in the cases with lymph node metastasis and in the tumor embolism cases; furthermore, the density became higher in relation to the increased T-stage and progression of cancer.CONCLUSION:
The VEGF-C expression and lymphatic vessel density appear to be prognostic factors for colon cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Colorectal Neoplasms
/
Chemotherapy, Adjuvant
/
Colonic Neoplasms
/
Lymphatic Vessels
/
Vascular Endothelial Growth Factor C
/
Lymph Nodes
/
Neoplastic Cells, Circulating
/
Neoplasm Metastasis
Type of study:
Practice guideline
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2007
Type:
Article
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