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The Significance of the Lymphatic Micro Vessel Density and Vascular Endothelial Growth Factor- C Expression for Colorectal Cancer
Journal of the Korean Surgical Society ; : 406-411, 2007.
Article in Korean | WPRIM | ID: wpr-148067
ABSTRACT

PURPOSE:

Studying the prognostic factors of distant metastasis is quite important for predicting these patients' prognosis and also for providing standards for post-operative adjuvant chemotherapy. Microbiological studies currently enable researchers to look for new predictors of distant metastasis in patients with colon cancers. In this study, the VEGF-C expression and stain rate of D2-40 were investigated as prognostic factors.

METHODS:

79 Specimens were collected from the patients who underwent colorectal operation and they were pathologicaly diagnosed with cancer at Chung-Ang University hospital from March, 2003 to Sept. 2005. The specimens were immunohistochemically stained to detect the VEGF-c expression and the D2- 40 stain rate.

RESULTS:

The VEGF-C expression was related to lymph node metastasis, tumor embolism and the frequency of the T- stage, but it was not related to progression of cancer. The D2-40 stained lymphatic density was significantly increased in the cases with lymph node metastasis and in the tumor embolism cases; furthermore, the density became higher in relation to the increased T-stage and progression of cancer.

CONCLUSION:

The VEGF-C expression and lymphatic vessel density appear to be prognostic factors for colon cancer.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Colorectal Neoplasms / Chemotherapy, Adjuvant / Colonic Neoplasms / Lymphatic Vessels / Vascular Endothelial Growth Factor C / Lymph Nodes / Neoplastic Cells, Circulating / Neoplasm Metastasis Type of study: Practice guideline / Prognostic study Limits: Humans Language: Korean Journal: Journal of the Korean Surgical Society Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Colorectal Neoplasms / Chemotherapy, Adjuvant / Colonic Neoplasms / Lymphatic Vessels / Vascular Endothelial Growth Factor C / Lymph Nodes / Neoplastic Cells, Circulating / Neoplasm Metastasis Type of study: Practice guideline / Prognostic study Limits: Humans Language: Korean Journal: Journal of the Korean Surgical Society Year: 2007 Type: Article