An Insertion/Deletion Polymorphism in the alpha(2B)-Adrenoceptor Gene is not a Genetic Risk Factor for Coronary Artery Disease in the Korean Population
Korean Circulation Journal
;
: 215-220, 2005.
Article
in Korean
| WPRIM
| ID: wpr-148142
ABSTRACT
BACKGROUND AND OBJECTIVES:
Cardiovascular disease (CVD) is a complex multigenic disorder, with significant inheritable elements having important roles relating to environmental factors. Recently, the alpha 2 adrenoceptor (alpha(2)-AR) gene has been reported to be involved in the development of coronary artery disease (CAD). The aim of this study was to investigate the relationships between an insertion/deletion (I/D) in alpha(2B)-AR and CAD in Korean subjects. SUBJECTS ANDMETHODS:
The alpha(2B)-AR I/D polymorphism, which was located in the third intracellular loop of the receptor polypeptide, was examined in 292 patients (MF=21973) with CAD and 151 healthy control subjects (MF=7081) who visited the Cardiovascular Genome Center in Yonsei Cardiovascular Hospital.RESULTS:
In the patient group, 77 men (35.1%) and 26 women (35.6%) had the I/I genotype; 105 men (47.9%) and 39 women (53.4%) a heterozygous genotype and 37 (17.0%) and 8 (11.0%) the D/D genotype. In the controls, 23 men (32.8%) and 29 women (35.8%) had the I/I genotype; 38 (54.3%) and 39 (48.1%) the I/D genotype and 9 (12.9%) and 13 (16.1%) the D/D genotype. There were no differences in the genotype frequencies between the patient and control groups, either in men or women. From a logistical regression analysis, the alpha(2B)-AR genotype was not significantly associated with CAD in our study group.CONCLUSION:
The alpha(2B)-AR I/D polymorphism is not a risk factor for CAD in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Coronary Artery Disease
/
Cardiovascular Diseases
/
Risk Factors
/
Genome
/
Coronary Vessels
/
Genotype
Type of study:
Etiology study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2005
Type:
Article
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