Validity of Glycated Hemoglobin in Screening and Diagnosing Type 2 Diabetes Mellitus in Chinese Subjects
The Korean Journal of Internal Medicine
;
: 41-46, 2012.
Article
in English
| WPRIM
| ID: wpr-148186
ABSTRACT
BACKGROUND/AIMS:
The application of glycated hemoglobin (HbA1c) for the diagnosis of diabetes is currently under extensive discussion. In this study, we explored the validity of using HbA1c as a screening and diagnostic test in Chinese subjects recruited in Nanjing, China.METHODS:
In total, 497 subjects (361 men and 136 women) with fasting plasma glucose (PG) > or = 5.6 mmol/L were recruited to undergo the oral glucose tolerance test (OGTT) and HbA1c test. Plasma lipid, uric acid, and blood pressure were also measured.RESULTS:
Using a receiver operating characteristic curve, the optimal cutoff point of HbA1c related to diabetes diagnosed by the OGTT was 6.3%, with a sensitivity and specificity of 79.6% and 82.2%, respectively, and the area under the curve was 0.87 (95% confidence interval, 0.83 to 0.92). A HbA1c level of 6.5% had a sensitivity and specificity of 62.7% and 93.5%, respectively. When comparing the HbA1c > or = 6.5% or OGTT methods for diagnosing diabetes, the former group had significantly higher HbA1c levels and lower levels of fasting and 2-hour PG than the latter group. No significant difference was observed in the other metabolism indexes between the two groups.CONCLUSIONS:
Our results suggest that HbA1c > or = 6.5% has reasonably good specificity for diagnosing diabetes in Chinese subjects, which is in concordance with the American Diabetes Association recommendations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Standards
/
Blood Glucose
/
Glycated Hemoglobin
/
Biomarkers
/
China
/
Mass Screening
/
Predictive Value of Tests
/
Reproducibility of Results
/
ROC Curve
/
Analysis of Variance
Type of study:
Diagnostic study
/
Practice guideline
/
Prognostic study
/
Screening study
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2012
Type:
Article
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