Bilateral Triple-Negative Invasive Breast Cancer with a BRCA2 Mutation, and Glioblastoma: A Case Report and Literature Review / 한국유방암학회지
Journal of Breast Cancer
;
: 108-111, 2017.
Article
in English
| WPRIM
| ID: wpr-148349
ABSTRACT
Breast cancer is the second leading cause of death among women in North America. Glioblastoma is the most common primary malignant central nervous system tumor in adults. The majority of hereditary breast cancers are associated with deleterious mutations in the BRCA1 and BRCA2 genes. Although few case reports have described the incidence of glioblastoma in patients previously diagnosed with breast cancer, any association between BRCA2 mutations and glioblastoma has not been demonstrated to date. Herein, we report a woman who is a carrier of a familial BRCA2 mutation, and was previously diagnosed with triple-negative breast cancer (TNBC) and subsequently with a second primary TNBC and glioblastoma. Further investigation is required to define the possible relationship between these two aggressive malignances and the BRCA2 mutation, which might be critical for the proper management and treatment of this disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast
/
Breast Neoplasms
/
Central Nervous System
/
Incidence
/
Cause of Death
/
Glioblastoma
/
Genes, BRCA2
/
Triple Negative Breast Neoplasms
/
North America
Type of study:
Incidence study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Journal of Breast Cancer
Year:
2017
Type:
Article
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