Evaluation of Atorvastatin for the Treatment of Patients With Asthma: A Double-Blind Randomized Clinical Trial
Allergy, Asthma & Immunology Research
;
: 290-294, 2012.
Article
in English
| WPRIM
| ID: wpr-148483
ABSTRACT
PURPOSE:
Statins are known as cholesterol-lowering agents, but have been suggested for the treatment of asthma because of their anti-inflammatory effects. In this study, the potential therapeutic effects of atorvastatin were investigated in asthmatic patients.METHODS:
A total of 62 patients with persistent mild to moderate asthma who presented at asthma clinics of Arak University of Medical Sciences were recruited in a double-blind randomized clinical trial. The asthma clinical control score was assessed based on the standardized Asthma Control Test. Lung volume, i.e., percentage of forced expiratory volume in one second (FEV1%) and percentage of forced vital capacity (FVC%), and peripheral blood eosinophils were also measured. The intervention group was treated with atorvastatin 40 mg per day for 8 weeks, while the control group received a placebo. Asthma controller treatments were not changed. At the beginning and end of the study, serum cholesterol and triglyceride levels were measured to evaluate adherence of the patients to the treatment.RESULTS:
The asthma control score did not significantly differ between the intervention and control groups (P=0.06). Difference in FEV1%, FVC%, and blood eosinophil count between the intervention and control groups were not statistically significant (P>0.05). The differences in post-treatment cholesterol and low-density lipoprotein cholesterol levels were significant (P<0.05).CONCLUSIONS:
Our study shows that atorvastatin is not effective in the treatment of persistent mild to moderate asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyrroles
/
Asthma
/
Vital Capacity
/
Forced Expiratory Volume
/
Cholesterol
/
Eosinophils
/
Atorvastatin
/
Heptanoic Acids
/
Lipoproteins
/
Lung
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2012
Type:
Article
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