Bidirectional ephrin signaling in bone
Osteoporosis and Sarcopenia
;
: 65-76, 2016.
Article
in English
| WPRIM
| ID: wpr-148713
ABSTRACT
The interaction between ephrin ligands (efn) and their receptors (Eph) is capable of inducing forward signaling, from ligand to receptor, as well as reverse signaling, from receptor to ligand. The ephrins are widely expressed in many tissues, where they mediate cell migration and adherence, properties that make the efn-Eph signaling critically important in establishing and maintaining tissue boundaries. The efn-Eph system has also received considerable attention in skeletal tissues, as ligand and receptor combinations are predicted to mediate interactions between the different types of cells that regulate bone development and homeostasis. This review summarizes our current understanding of efn-Eph signaling with a particular focus on the expression and functions of ephrins and their receptors in bone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Osteoclasts
/
Bone Development
/
Cell Movement
/
Ephrins
/
Homeostasis
/
Ligands
Language:
English
Journal:
Osteoporosis and Sarcopenia
Year:
2016
Type:
Article
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