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Up-Regulation of Cyclooxygenase 2 and Matrix Metalloproteinases-2 and -9 in Cutaneous Squamous Cell Carcinoma: Active Role of Inflammation and Tissue Remodeling in Carcinogenesis
Annals of Dermatology ; : 145-151, 2013.
Article in English | WPRIM | ID: wpr-148978
ABSTRACT

BACKGROUND:

Tissue inflammation and remodeling have been extensively studied in various tumors in relation with their invasiveness and metastasis.

OBJECTIVE:

The purpose of this study was to investigate the change in tissue inflammation and remodeling markers in cutaneous squamous cell carcinoma (SCC).

METHODS:

Expression levels of cyclooxygenase-2 (COX-2) as an inflammatory marker and matrix metalloproteinases-2 and -9 (MMPs 2/9) as remodeling markers were studied in mouse and human SCCs. Western blot analysis and RT-PCR for COX-2 and MMPs 2/9 were performed with skin samples from SCC patients and chronic ultraviolet B (UVB)-induced SCC from hairless mice.

RESULTS:

mRNA and protein levels of COX-2 and MMPs 2/9 were up-regulated with the higher sensitivity for MMP-9 in mouse SCCs, which were induced by chronic UVB irradiation. Consistently, COX-2 and MMPs 2/9 were up-regulated with the higher sensitivity for MMP-9 in human SCCs.

CONCLUSION:

COX-2 and MMPs 2/9 are up-regulated in well-differentiated cutanous SCC. Our findings indicate that inflammatory and tissue remodeling processes are actively induced during carcinogenesis of cutaneous SCC.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / RNA, Messenger / Carcinoma, Squamous Cell / Up-Regulation / Blotting, Western / Prostaglandin-Endoperoxide Synthases / Matrix Metalloproteinases / Cyclooxygenase 2 / Inflammation Limits: Animals / Humans Language: English Journal: Annals of Dermatology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / RNA, Messenger / Carcinoma, Squamous Cell / Up-Regulation / Blotting, Western / Prostaglandin-Endoperoxide Synthases / Matrix Metalloproteinases / Cyclooxygenase 2 / Inflammation Limits: Animals / Humans Language: English Journal: Annals of Dermatology Year: 2013 Type: Article