Up-Regulation of Cyclooxygenase 2 and Matrix Metalloproteinases-2 and -9 in Cutaneous Squamous Cell Carcinoma: Active Role of Inflammation and Tissue Remodeling in Carcinogenesis
Annals of Dermatology
;
: 145-151, 2013.
Article
in English
| WPRIM
| ID: wpr-148978
ABSTRACT
BACKGROUND:
Tissue inflammation and remodeling have been extensively studied in various tumors in relation with their invasiveness and metastasis.OBJECTIVE:
The purpose of this study was to investigate the change in tissue inflammation and remodeling markers in cutaneous squamous cell carcinoma (SCC).METHODS:
Expression levels of cyclooxygenase-2 (COX-2) as an inflammatory marker and matrix metalloproteinases-2 and -9 (MMPs 2/9) as remodeling markers were studied in mouse and human SCCs. Western blot analysis and RT-PCR for COX-2 and MMPs 2/9 were performed with skin samples from SCC patients and chronic ultraviolet B (UVB)-induced SCC from hairless mice.RESULTS:
mRNA and protein levels of COX-2 and MMPs 2/9 were up-regulated with the higher sensitivity for MMP-9 in mouse SCCs, which were induced by chronic UVB irradiation. Consistently, COX-2 and MMPs 2/9 were up-regulated with the higher sensitivity for MMP-9 in human SCCs.CONCLUSION:
COX-2 and MMPs 2/9 are up-regulated in well-differentiated cutanous SCC. Our findings indicate that inflammatory and tissue remodeling processes are actively induced during carcinogenesis of cutaneous SCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
RNA, Messenger
/
Carcinoma, Squamous Cell
/
Up-Regulation
/
Blotting, Western
/
Prostaglandin-Endoperoxide Synthases
/
Matrix Metalloproteinases
/
Cyclooxygenase 2
/
Inflammation
Limits:
Animals
/
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2013
Type:
Article
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