Reevaluation of the Neonatal Screening Test for Congenital Hypothyroidism / 소아과
Korean Journal of Pediatrics
;
: 387-394, 2005.
Article
in Korean
| WPRIM
| ID: wpr-148996
ABSTRACT
PURPOSE:
We performed this study to compare the TSH and free T4 levels according to gestational age and birth weight, and to reevaluate the cut-off values in the neonatal screening test for congenital hypothyroidism.METHODS:
Total 2,133 neonates(1,749 healthy newborns and 384 sick neonates) were screened in Dankook University Hospital from May 2000 to January 2003. Neonates with abnormal TSH values (higher than 20 microliterU/mL) or abnormal free T4 levels(lower than 1 ng/dL) were recalled to recheck the thyroid function test. At that time, physical examinations and history-taking regarding perinatal problem, medication history, and mother's illness were undertaken.RESULTS:
Serum TSH and free T4 values revealed no significant difference according to sex, delivery type, and Apgar score. The free T4 levels showed statistically significant differences, with gestational age or birth weight(P20 microliterU/mL or free T4<1 ng/dL was relatively high, it was impossible to set up new cut-off values without compromising sensitivity. We think studies including a larger study population will be required to change the cut-off values.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apgar Score
/
Physical Examination
/
Thyroid Function Tests
/
Birth Weight
/
Mass Screening
/
Gestational Age
/
Neonatal Screening
/
Congenital Hypothyroidism
/
Parturition
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Humans
/
Infant, Newborn
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2005
Type:
Article
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