Two Cases of Bone Marrow Permeated Primary Gastric Mucosa-Associated Lymphoid Tissue Lymphoma / 대한임상병리학회지

ABSTRACT

Mucosa-associated lymphoid tissue (MALT) lymphoma has several characters different from those of nodal lymphoma. Histologically, MALT lymphoma is mainly composed of centrocyte-like cells and other heterogeneous cells, and is classified as high grade and low grade by the proportion of blasts. Most of MALT lymphoma is initially diagnosed as localized disease, and has slow progression and relatively longer disease-free survival time. The rate of bone marrow permeation of MALT lymphoma is reported variable from 8% to 45% by previous other country reports. We report 2 cases of bone marrow permeated MALT lymphoma, for MALT lymphoma has lower incidence than that of nodal lymphoma and no marrow permeated cases have been reported in Korea. Fifty six-year-old male who complained dyspepsia is diagnosed as MALT lymphoma by biopsy of gastric angle. His bone marrow biopsy showed well demarcated paratrabecular neoplastic lymphoid cell infiltration. The other case is 78-year-old female who had epigastric pain. She was diagnosed as MALT lymphoma of gastric angle, and her bone marrow biopsy showed poorly demarcated nodal infiltration of neoplastic lymphoid cells.