Experimental Exudative Retinal Detachment in Albino Rats

ABSTRACT

To establish animal model of exudative retinal detachment in Sprague Dawley albino rats and to elucidate the possible role of retinal vein in the induction of exudative retinal detachments, rose bengal photosensitive dye was injected intravenously and argon laser was applied. In group A(10 eyes), laser was applied on intervascular retinal areas linearly. In group B (12 eyes), laser was applied on major retinal veins. In group C(4 eyes), laser was applied on major retinal arteris. In group D(3 eyes), laser was applied on major retinal veins without rose bengal dye and in group E(26 eyes), only the rose bengal dye was perfused. And in group F(3 eyes), normal eyes were fixed for negative controls. Exudative bullous retinal detachment occurred only in group B and these resutls were confirmed in histological examinations. In control groups (D and E), tissue injuries were not found. In conclusion, exudative retinal detachment could be induced by occlusion of retinal veins in albino rats and the abnormalities of retinal venous blood flow were required for the induction of exudative retinal detachment.