A Case of Ectopic Adrenocorticotropic Hormone Syndrome in Small Cell Lung Cancer / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 436-439, 2015.
Article
in English
| WPRIM
| ID: wpr-149065
ABSTRACT
Small cell lung cancer (SCLC), which originated from neuroendocrine tissue, can develop into paraneoplastic endocrine syndromes, such as Cushing syndrome, because of an inappropriate secretion of ectopic adrenocorticotropic hormone (ACTH). This paraneoplastic syndrome is known to be a poor prognostic factor in SCLC. The reason for poor survival may be because of a higher risk of infection associated with hypercortisolemia. Therefore, early detection and appropriate treatment for this syndrome is necessary. But the diagnosis is challenging and the source of ACTH production can be difficult to identify. We report a 69-year-old male patient who had severe hypokalemia, metabolic alkalosis, and hypertension as manifestations of an ACTH-secreting small cell carcinoma of the lung. He was treated with ketoconazole and spironolactone to control the ACTH dependent Cushing syndrome. He survived for 15 months after chemotherapy, which is unusual considering the poor outcome of the ectopic ATH syndrome associated with SCLC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraneoplastic Syndromes
/
Spironolactone
/
ACTH Syndrome, Ectopic
/
Carcinoma, Small Cell
/
Adrenocorticotropic Hormone
/
Cushing Syndrome
/
Diagnosis
/
Drug Therapy
/
Alkalosis
/
Small Cell Lung Carcinoma
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2015
Type:
Article
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