Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects
Gut and Liver
;
: 464-469, 2015.
Article
in English
| WPRIM
| ID: wpr-149104
ABSTRACT
BACKGROUND/AIMS:
Postprandial symptoms of fullness and abdominal discomfort are common after fatty meals. Gastric lipases hydrolyze 10% to 20% of dietary triglycerides during the stomach trituration period of digestion. The aim of this study was to evaluate the effects of acid-resistant lipase on upper gastrointestinal symptoms, including fullness and bloating, as well as on gastric myoelectrical activity after healthy subjects ingested a high-fat, liquid meal.METHODS:
This study utilized a double-blind, placebo-controlled, crossover design with 16 healthy volunteers who ingested either a capsule containing 280 mg of acid-resistant lipase or a placebo immediately before a fatty meal (355 calories, 55% fat). Participants rated their stomach fullness, bloating, and nausea before and at timed intervals for 60 minutes after the meal. Electrogastrograms were obtained to assess the gastric myoelectrical activity.RESULTS:
Stomach fullness, bloating, and nausea increased significantly 10 minutes after ingestion of the fatty meal (p<0.01), whereas normal gastric myoelectrical activity decreased and tachygastria increased (p<0.05). With lipase, reports of stomach fullness were significantly lower compared with placebo (p<0.05), but no effect on gastric myoelectrical activity or other upper gastrointestinal symptoms was observed.CONCLUSIONS:
The high-fat meal induced transient fullness, bloating, nausea, and tachygastria in healthy individuals, consistent with post-prandial distress syndrome. Acid-resistant lipase supplementation significantly decreased stomach fullness.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach
/
Abdominal Pain
/
Double-Blind Method
/
Myoelectric Complex, Migrating
/
Cross-Over Studies
/
Postprandial Period
/
Dietary Supplements
/
Dyspepsia
/
Diet, High-Fat
/
Meals
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Gut and Liver
Year:
2015
Type:
Article
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