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Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects
Gut and Liver ; : 464-469, 2015.
Article in English | WPRIM | ID: wpr-149104
ABSTRACT
BACKGROUND/

AIMS:

Postprandial symptoms of fullness and abdominal discomfort are common after fatty meals. Gastric lipases hydrolyze 10% to 20% of dietary triglycerides during the stomach trituration period of digestion. The aim of this study was to evaluate the effects of acid-resistant lipase on upper gastrointestinal symptoms, including fullness and bloating, as well as on gastric myoelectrical activity after healthy subjects ingested a high-fat, liquid meal.

METHODS:

This study utilized a double-blind, placebo-controlled, crossover design with 16 healthy volunteers who ingested either a capsule containing 280 mg of acid-resistant lipase or a placebo immediately before a fatty meal (355 calories, 55% fat). Participants rated their stomach fullness, bloating, and nausea before and at timed intervals for 60 minutes after the meal. Electrogastrograms were obtained to assess the gastric myoelectrical activity.

RESULTS:

Stomach fullness, bloating, and nausea increased significantly 10 minutes after ingestion of the fatty meal (p<0.01), whereas normal gastric myoelectrical activity decreased and tachygastria increased (p<0.05). With lipase, reports of stomach fullness were significantly lower compared with placebo (p<0.05), but no effect on gastric myoelectrical activity or other upper gastrointestinal symptoms was observed.

CONCLUSIONS:

The high-fat meal induced transient fullness, bloating, nausea, and tachygastria in healthy individuals, consistent with post-prandial distress syndrome. Acid-resistant lipase supplementation significantly decreased stomach fullness.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach / Abdominal Pain / Double-Blind Method / Myoelectric Complex, Migrating / Cross-Over Studies / Postprandial Period / Dietary Supplements / Dyspepsia / Diet, High-Fat / Meals Type of study: Controlled clinical trial Limits: Adult / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach / Abdominal Pain / Double-Blind Method / Myoelectric Complex, Migrating / Cross-Over Studies / Postprandial Period / Dietary Supplements / Dyspepsia / Diet, High-Fat / Meals Type of study: Controlled clinical trial Limits: Adult / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2015 Type: Article