A Randomized Crossover Study of the Additive Effect of Lercanidipine and Indapamide in Patients with the Mild to Moderate Hypertension
Korean Circulation Journal
;
: 854-859, 2005.
Article
in Korean
| WPRIM
| ID: wpr-149129
ABSTRACT
BACKGROUND AND OBJECTIVES:
There is evidence available from randomized control trials about the additive effects of combination regimens that are mainly based on diuretics and beta-blockers or ACE inhibitors. Yet there are some arguments about the effect of the combination of calcium channel blockers (CCBs) and diuretics. We aimed to study the blood pressure-lowering effects of lercanidipine, indapamide or a combination therapy on the home blood pressure (HBP) and the 24-hour ambulatory blood pressure (ABP), and we wanted to examine the agreement with using these two methods. SUBJECTS ANDMETHODS:
70 patients participated in this randomized open crossover design study. The treatments in each phase were 10 mg lercanidipine (L) and 1 mg indapamide (I), separately and also in combination (L+I). Each patient had their HBP checked twice during each phase and the 24h ABP was checked in two of the 3 phases. We also measured the agreement between the HBP and ABP by using a Bland-Altman plot.RESULTS:
58 patients (mean age 49+/-9 (31-71) years; 37 males and 21 females) completed the study. The blood pressure was significantly reduced during all the active treatments compared with the baseline (L 160.2+/-12/100.3+/-9 mmHg, I; 130.5+/-9.3/86.0+/-8.1 mmHg, 129.2+/-12.9/83.9+/-11.1 mmHg, L+I124.9+/-10.9/81.3+/-8.5 mmHg, p<.000) and the BP for the combination therapy was also significantly less than those BPs for both the other monotherapies (L+I vs. L p<.002, L+I vs. I p<.01) by measuring the 24h ABP. The Bland-Altman plot showed+/-25 mmHg for the limit of agreement between both measurement methods.CONCLUSION:
CCB and diuretics were effective agents for treating hypertensive patients. As a combination therapy, the effects on blood pressure are additive. Poor agreement of the blood pressures with using the two measurement methods was observed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Pressure
/
Angiotensin-Converting Enzyme Inhibitors
/
Calcium Channel Blockers
/
Cross-Over Studies
/
Blood Pressure Monitoring, Ambulatory
/
Diuretics
/
Hypertension
/
Indapamide
Type of study:
Controlled clinical trial
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2005
Type:
Article
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