Breakthrough in heart failure with preserved ejection fraction: are we there yet?
The Korean Journal of Internal Medicine
; : 1-14, 2016.
Article
in En
| WPRIM
| ID: wpr-149380
Responsible library:
WPRO
ABSTRACT
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A novel paradigm has recently emerged, in which central roles are ascribed to systemic inflammation and generalized endothelial dysfunction in the pathophysiology of HFPEF. In this review, we discuss the role of the endothelium in cardiovascular homeostasis and how deranged endothelial-related signaling pathways contribute to the development of HFPEF. We also review the novel therapies in various stages of research and development that target different components of this signaling pathway.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Stroke Volume
/
Endothelium, Vascular
/
Signal Transduction
/
Risk Factors
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Ventricular Function, Left
/
Inflammation Mediators
/
Heart Failure
/
Inflammation
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
The Korean Journal of Internal Medicine
Year:
2016
Type:
Article