Immunoglobulin Gene Repertoire In Rheumatoid Synovium As A Model For Autoimmune Disease / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 200-212, 1994.
Article
in Korean
| WPRIM
| ID: wpr-149478
ABSTRACT
OBJECTIVE:
To gain insights into structural characteristics of immunoglobulin kappa chain repertoire expressed in the inflammed synovium of rheumatoid arthritis (RA), we analyzed V kappa transcirpts expressed in the synovium of a patient with longstanding RA and compared to those expressed in the PBLs of RA and normal controls.METHODS:
RT-PCR was done to amplify kappa chain transcripts from RA synovial lymphocytes and the cDNA sequences were compared to those from PBL of RA patient or normal control.RESULTS:
Kappa chain repertoire from RA patient's synovial lymphocytes or PBL revealed increased somatic mutation and unusually long complementarity determining region (CDR) 3 compared to normal control.CONCLUSIONS:
These changes in kappa chain repertoire in RA patient are suggesting that the antibody repertoire expressed in the synovium or PBL is unique and may be related with systemic dysregulation of B cell development
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Autoimmune Diseases
/
Synovial Membrane
/
Immunoglobulins
/
Genes, Immunoglobulin
/
Lymphocytes
/
Immunoglobulin kappa-Chains
/
DNA, Complementary
/
Complementarity Determining Regions
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
1994
Type:
Article
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