Clinical Manifestations On Systemic Lupus Erythematosus / 대한류마티스학회지

ABSTRACT

OBJECTIVE: Systemic lupus erythematceus(SLE) is an autoimmune disease and manifests with a variety of clinical and immunologic features in the multisystem SLE occurs worldwide in all ethnic groups but the prevalence and clinical man'ifestations of SLE may differ depending on ethnic groups and age. METHODS: We retrospectively analyzed the clinical and laboratory features of 167 patients with SLE at the Yeungnam University Hospital, Kyungpook National University Hospital and Keimyung University Hospital between January 1984 to February 1993. RESULTS: 1) The male to female ratio was 119.8 and the mean age was 28.1. Seventy six patients(42. 1%) were diagnosed to have SLE in the third decade. 2) The prevalence of positive ARA criteria for SLE revealed that antinuclear antibody (ANA) was 96.4%, cutaneous disorder 73.6%, hematologic disorder 72.5%, immunologic disorder 71.3%, arthralgia or arthritis 70.1%, renal disorder 55.7%, serositis 40.7%, oral ulcer 28.7% photosensitivity 25.7% and neuropsychiatric disorder 19.7%. 3) The malar rash was the most common manifestation in mucocutaneous disorder, arthralgia or arthritis in musculoskeletal disorder, proteinuria in renal disorder, pericarditis and pleuritis in cardiopulmonary disorder, psychosis in neuropsychiatric disorder, anemia in hematologic disorder, and hypocomplementemia in immunologic disorder. 4) Renal biopsy was performed in 65 cases among which the most common histologic type was diffuse proliferative glomerulonephritis(53.9%). CONCLUSION: These data suggested that clinical manifestations of SLE in Korean patients revealed similar to those of Western(Caucasian+Black) except that photosensitivity, serositis, neuropsychiatric disorders were less frequent in Korean.