Measurement of hepatic venous pressure gradient in liver cirrhosis: Relationship with the status of cirrhosis, varices, and ascites in Korea / 대한간학회지
The Korean Journal of Hepatology
;
: 150-158, 2008.
Article
in Korean
| WPRIM
| ID: wpr-149507
ABSTRACT
BACKGROUND/AIMS:
The relationships between the hepatic venous pressure gradient (HVPG) and the status of cirrhosis, complications of portal hypertension and the severity of cirrhosis are not clear. The aim of this study was to determine the relationships between HVPG and the complications or status of cirrhosis.METHODS:
The HVPG, gastroesophageal varices, Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, presence of ascites, recent bleeding history and the status of cirrhosis were assessed in a cohort of 172 patients (156 males, 16 females) with liver cirrhosis.RESULTS:
The HVPG was 15.6+/-5.1 (mean+/-SD) mmHg (4-33 mmHg) and was significantly higher in patients in the decompensated stage than in those in the compensated stage (16.6+/-4.3 vs. 10.8+/-6.1 mmHg, respectively; P0.05). HVPG was significantly higher in Child's B cirrhosis (n=87, 15.6+/-4.7 mmHg) and Child's C cirrhosis (n=36, 18.4+/-4.7 mmHg) than in Child's A cirrhosis (n=49, 13.7+/-5.1 mmHg; P<0.01). HVPG also was strongly correlated with the MELD score (P<0.01). The time required to measure the HVPG was 11.2+/-6.4 min, and only three cases of minor complication occurred during the procedure.CONCLUSIONS:
HVPG was correlated with the severity of liver cirrhosis, presence of ascites, and risk of variceal bleeding in patients with liver cirrhosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ascites
/
Venous Pressure
/
Severity of Illness Index
/
Esophageal and Gastric Varices
/
Predictive Value of Tests
/
ROC Curve
/
Cohort Studies
/
Data Interpretation, Statistical
/
Hepatic Veins
/
Hypertension, Portal
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
The Korean Journal of Hepatology
Year:
2008
Type:
Article
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