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Correlations between Glucagon Stimulated C-peptide Levels and Microvascular Complications in Type 2 Diabetes Patients
Diabetes & Metabolism Journal ; : 379-387, 2012.
Article in English | WPRIM | ID: wpr-14951
ABSTRACT

BACKGROUND:

This study aimed to investigate whether stimulated C-peptide is associated with microvascular complications in type 2 diabetes mellitus (DM).

METHODS:

A cross-sectional study was conducted in 192 type 2 diabetic patients. Plasma basal C-peptide and stimulated C-peptide were measured before and 6 minutes after intravenous injection of 1 mg glucagon. The relationship between C-peptide and microvascular complications was statistically analyzed.

RESULTS:

In patients with retinopathy, basal C-peptide was 1.9+/-1.2 ng/mL, and stimulated C-peptide was 2.7+/-1.6 ng/mL; values were significantly lower compared with patients without retinopathy (P=0.031 and P=0.002, respectively). In patients with nephropathy, basal C-peptide was 1.6+/-0.9 ng/mL, and stimulated C-peptide was 2.8+/-1.6 ng/mL; values were significantly lower than those recorded in patients without nephropathy (P=0.020 and P=0.026, respectively). Stimulated C-peptide level was associated with increased prevalence of microvascular complications. Age-, DM duration-, and hemoglobin A1c-adjusted odds ratios for retinopathy in stimulated C-peptide value were 4.18 (95% confidence interval [CI], 1.40 to 12.51) and 3.35 (95% CI, 1.09 to 10.25), respectively. The multiple regression analysis between nephropathy and C-peptide showed that stimulated C-peptide was statistically correlated with nephropathy (P=0.03).

CONCLUSION:

In patients with type 2 diabetes, the glucagon stimulation test was a relatively simple method of short duration for stimulating C-peptide response. Stimulated C-peptide values were associated with microvascular complications to a greater extent than basal C-peptides.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / C-Peptide / Hemoglobins / Glucagon / Odds Ratio / Prevalence / Cross-Sectional Studies / Diabetes Mellitus, Type 2 / Injections, Intravenous Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Humans Language: English Journal: Diabetes & Metabolism Journal Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / C-Peptide / Hemoglobins / Glucagon / Odds Ratio / Prevalence / Cross-Sectional Studies / Diabetes Mellitus, Type 2 / Injections, Intravenous Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Humans Language: English Journal: Diabetes & Metabolism Journal Year: 2012 Type: Article