A Case of Endoscopically Complete Remission of Esophageal Neuroendocrine Tumors by Concurrent Chemoradiation Therapy / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 265-269, 2016.
Article
in English
| WPRIM
| ID: wpr-149529
ABSTRACT
Neuroendocrine tumors (NETs) of the esophagus are extremely rare, aggressive and have a poor prognosis. Combined therapy using chemotherapy, radiotherapy and/or surgery appear effective. Here, we present a patient with a complaint of dysphagia who was diagnosed with this rare tumor. Upper gastrointestinal endoscope of a 46-year-old female revealed a localized ulcerative lesion in the middle esophagus. Histologic exam of biopsy specimens indicated a neuroendocrine carcinoma. The tumor cells were arranged in microtubular structures, with small and round cells containing scanty cytoplasm. They were positive for synaptophysin and chromogranin A on immunohistochemical staining. A computed tomography scan showed an esophageal tumor with enlarged superior mediastinal lymph nodes and about 1.2 cm sized liver metastasis, similar to findings in PET-CT scanning. The patient was prescribed chemotherapy consisting of etoposide and cisplatin, which led to regression of disease on follow-up imaging study. She continues under clinical observation. We seek to increase awareness of this exceedingly rare but hazardous disease by sharing our unexpected finding.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Radiotherapy
/
Ulcer
/
Biopsy
/
Esophageal Neoplasms
/
Deglutition Disorders
/
Follow-Up Studies
/
Cisplatin
/
Synaptophysin
/
Neuroendocrine Tumors
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
The Korean Journal of Gastroenterology
Year:
2016
Type:
Article
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