Risk Factors for Post-Lumbar Puncture Headache in a Study of Alzheimer's Disease Biomarkers
Dementia and Neurocognitive Disorders
;
: 12-16, 2015.
Article
in English
| WPRIM
| ID: wpr-150107
ABSTRACT
BACKGROUND AND PURPOSE:
In memory clinics, the lumbar puncture (LP) is increasingly being used to evaluate cerebrospinal fluid for biomarkers of Alzheimer's disease (AD). Post-lumbar puncture headache (PLPH) is the most frequent complication of LP, and can prove to be a barrier for the performance of LP.METHODS:
We retrospectively collected data from 59 subjects (patients with AD and cognitively healthy controls) who were enrolled in a study aimed to identify AD biomarkers via LP. In order to determine whether subjects experienced PLPH, we assessed recorded follow-up telephone interviews. To analyze the association between the occurrence of PLPH and several demographic- and procedure-related factors, a multiple logistic regression analysis with backward stepwise method was performed.RESULTS:
The overall frequency of PLPH was 49.15%. PLPH was more frequent in younger subjects and clinical diagnosis was associated with PLPH. The use of cutting-edge needles was also suggested as a statistically significant factor in the development of PLPH, and was determined to be the only factor that could be modified in order to lower the frequency of PLPH.CONCLUSIONS:
Age, clinical diagnosis, and needle type were all determined to be predictive factors of PLPH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Puncture
/
Biomarkers
/
Logistic Models
/
Cerebrospinal Fluid
/
Interviews as Topic
/
Retrospective Studies
/
Risk Factors
/
Follow-Up Studies
/
Diagnosis
/
Post-Dural Puncture Headache
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Qualitative research
Language:
English
Journal:
Dementia and Neurocognitive Disorders
Year:
2015
Type:
Article
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