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Multiple Myeloma in a Patient with Acromegaly
Endocrinology and Metabolism ; : 110-115, 2015.
Article in English | WPRIM | ID: wpr-150110
ABSTRACT
Acromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients with acromegaly, and insulin-like growth factor 1 (IGF-1) is known to influence tumor formation by increasing cell proliferation and inhibiting apoptosis. Multiple myeloma (MM) is a plasma cell neoplasm, and previous studies have suggested the possible role of IGF-1 in its development of MM. However, no cases of acromegaly accompanied with MM have been reported in Asia to date. We here report the case of a 58-year-old woman with acromegaly accompanied with MM who presented with longstanding acromegalic manifestations resulting from a GH-secreting pituitary adenoma and also exhibited anemia, a reversed albumin/globulin ratio, and plasmacytosis on bone marrow examination. Because IGF-1 has been suggested to play an important role in the development and progression of MM, the patient promptly underwent surgical removal of the pituitary adenoma via a transsphenoidal approach. Since there is currently no consensus on therapeutic guidelines and suggested prognosis for MM with acromegaly, long-term follow-up of such cases is needed.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pituitary Neoplasms / Prognosis / Asia / Acromegaly / Bone Marrow Examination / Insulin-Like Growth Factor I / Growth Hormone / Mortality / Apoptosis / Consensus Type of study: Practice guideline / Prognostic study Limits: Female / Humans Country/Region as subject: Asia Language: English Journal: Endocrinology and Metabolism Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pituitary Neoplasms / Prognosis / Asia / Acromegaly / Bone Marrow Examination / Insulin-Like Growth Factor I / Growth Hormone / Mortality / Apoptosis / Consensus Type of study: Practice guideline / Prognostic study Limits: Female / Humans Country/Region as subject: Asia Language: English Journal: Endocrinology and Metabolism Year: 2015 Type: Article