A Comparison of the Clinicopathologic and Prognostic Differences in Patients Who Underwent Hepatic Resection with Hepatitis B- versus Hepatitis C-related Hepatocellular Carcinoma / 한국간담췌외과학회지

ABSTRACT

BACKGROUND/AIMS: The surgical outcomes for patients with HCC according to different hepatitis viral status have been inconsistently reported. This study evaluated the clinico-pathological and prognostic differences in patients with HBV- and HCV-related HCC. METHODS: Two hundred and eleven patients with HCC who underwent curative hepatic resection were categorized into three groups according to viral status: Group I (Hbs Ag (+) HCV Ab (-), n=116); Group II (Hbs Ag (-) HCV Ab (+), n=74); Group III (Hbs Ag (-) HCV Ab (-), n=17). The clinical manifestations, pathologic features, and treatment outcomes were compared. RESULTS: The average age at onset of HCV-related HCC is older than that of HBV-related HCC. Most HCV-related HCC is associated with liver cirrhosis as reflected by lower albumin level, platelet count, higher ICG R15 value, ALT levels. and frequency of minor resection (P<0.05). The incidence of portal vein invasion or intrahepatic metastasis did not differ among groups. In addition, HCV Ab (+) group had significantly lower disease free survival rates (P<0.05). CONCLUSION: This study suggests that the patients with HCV- related HCC have poorer liver function with more frequent recurrence.